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Year : 2018  |  Volume : 18  |  Issue : 5  |  Page : 13-14

OSC16: Effects of streptozotocin-induced diabetes mellitus on peri-implantitis

Date of Web Publication31-Oct-2018

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-4052.244606

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How to cite this article:
... OSC16: Effects of streptozotocin-induced diabetes mellitus on peri-implantitis. J Indian Prosthodont Soc 2018;18, Suppl S1:13-4

How to cite this URL:
... OSC16: Effects of streptozotocin-induced diabetes mellitus on peri-implantitis. J Indian Prosthodont Soc [serial online] 2018 [cited 2019 Mar 23];18, Suppl S1:13-4. Available from: http://www.j-ips.org/text.asp?2018/18/5/13/244606

Seiya Yamazaki1, Chihiro Masaki1, Tomotaka Nodai1, Akiko Tamura1, Shintaro Tsuka1, Taro Mukaibo1, Yusuke Kondo1, Kentaro Ono2, Ryuji Hosokawa1

1Division of Oral Reconstruction and Rehabilitation, Kyushu Dental University, Kitakyushu, Japan, 2Division of Physiology, Kyushu Dental University, Kitakyushu, Japan

Aim: Diabetes mellitus (DM) is a risk factor associated with dental implant failure. However, the influence of DM on peri-implantitis is not fully understood. The aim of this study was to assess the effects of hyperglycaemia state after osseointegration on peri-implant bone defects of ligature-induced peri-implantitis in rats.

Materials and Methods: Twenty-four male Wistar rats at 5 weeks of age were used. Four weeks after extraction of maxillary first molars, titanium implants (1.8 x 2 mm) were placed. After one month of healing, the healing abutments were installed. The rats were divided into control (N-DM), diabetic (DM) and insulin groups (DM-I). DM group was induced by a single injection of 50mg/kg streptozotocin (STZ). N-DM group received only saline. DM-I group received subcutaneous dose of insulin twice a day. Silk ligatures were placed sub-marginally around the abutments only on the right side (ligature side) to induce plaque associated peri-implant inflammation. The implants on the left side were not ligated (non-ligature side). The samples were analysed radiologically to measure bone level change at 28 days after ligature.

Results: Micro-CT revealed significantly greater bone loss at DM group compared to N-DM group on the non-ligature side. On the other hand, the alveolar bone loss progression was observed on the ligature side in all groups. However, there are no significant differences between three groups.

Conclusion: Within the limitations of the animal study, these results suggested that poor glycaemic control and poor plaque control after osseointegration leads to an increased risk for peri-implantitis.


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