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ORIGINAL STUDY NON-COMPETITION
Year : 2018  |  Volume : 18  |  Issue : 5  |  Page : 34

OSNC12: Repetitive occlusal interferences facilitate masseter hyperalgesia in rats


Date of Web Publication31-Oct-2018

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-4052.244653

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How to cite this article:
. OSNC12: Repetitive occlusal interferences facilitate masseter hyperalgesia in rats. J Indian Prosthodont Soc 2018;18, Suppl S1:34

How to cite this URL:
. OSNC12: Repetitive occlusal interferences facilitate masseter hyperalgesia in rats. J Indian Prosthodont Soc [serial online] 2018 [cited 2018 Nov 20];18, Suppl S1:34. Available from: http://www.j-ips.org/text.asp?2018/18/5/34/244653



Siyi Mo, Xiaoxiang Xu, Ye Cao, Huifei Jie, Qiufei Xie

Department of Prosthodontics, Center for Oral Functional Diagnosis, Treatment and Research, Peking University School and Hospital of Stomatology, Beijing, China

Aim: To investigate the effect of orofacial pain history on masticatory muscle pain (MMP) induced with repetitive occlusal interferences (OIs) in rats.

Materials and Methods: Twenty Sprague-Dawley male rats were randomly assigned into four groups with the approval of ethic committee. The 0.4 mm-thick metal crown was bonded on the upper first molar of rat as the first OI and removed after 2 days. At 7 days after the head withdrawal mechanical threshold (HWMT) recovering to baseline, the same crown was bonded again as the second OI and removed after 2 or 4 days. Operations were simulated without bonding any appliance in the control group. HWMT of bilateral masseters were measured with von-Frey anesthesiometer while morphological changes of astrocyte and microglia in trigeminal spinal nucleus (Vsp) were observed using immunofluorescent staining before and after the first and second OIs in each group.

Results: The recovery of masseter HWMT needed 8 days or 10 days respectively after removing the first OI or the 2-day second OI. The masseter HWMT required 19 days or 12 days respectively to recover with or without the first OI after removing the 4-day second OI. At 19 days after removing the 4-day second OI, the astrocyte showed mild activation regardless with or without the first OI, while the microglia showed mild activation only with the first OI.

Conclusion: The repetitive occlusal interferences facilitated masseter hyperalgesia by postponing the relief of masseter hyperalgesia and prolonging microglia activation in Vsp.






 

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